The predictive validity of submaximal OUES was derived. Minute ventilation and oxygen consumption were measured, and OUES was calculated, compared with healthy reference values, and correlated with the peak oxygen consumption. Patients underwent cardiopulmonary exercise testing to assess cardiorespiratory fitness. Thirty-seven stroke patients were classified into 2 groups according to their Brunnstrom stage of affected lower limbs. Hence, we designed this observational study to investigate the application of the OUES for evaluating aerobic capacity in these patients. Oxygen uptake efficiency slope (OUES) could represent the aerobic capacity in submaximal exercise test. To evaluate the real aerobic capacity is difficult due to impaired limbs function in stroke patients. Our findings revealed that O2peak is dependent on the severity of hemiparesis in leg, and along with ΔO2/ΔWR closely related to the severity of hemiparesis in post-acute stroke patients, regardless of the types and locations of lesion after stroke, as well as the differences in comorbidities and medications. The relations were consistent after adjustment for age, sex, body mass index, stroke type, hemiparetic side, modified Ashworth Scale, time poststroke, comorbidities, and medications. ΔV˙O2/ΔWR was higher for the group with increased BMRSL. V˙O2peak was 10% lower in hemiparetic leg with BMRSL V than in that with BMRSL VI, 20% lower in BMRSL IV, and 50% lower in BMRSL III. Severity of the hemiparetic lower limb was assessed by Brunnstrom's motor recovery stages lower extremity (BMRSL). Mean peak V˙O2(V˙O2peak) and work efficiency (ΔV˙O2/ΔWR) were measured by open-circuit spirometry during standard upright ergometer cycling. Sixty-four patients with a mean poststroke interval of 8.6 ± 3.8 days underwent a ramp cardiopulmonary exercise test on a cycling ergometer to volitional termination. This study evaluated the impact of severity of hemiparesis on oxygen uptake (V˙O2) response in post-acute stroke patients.
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